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{% extends "layout.html" %} {% block title %}IMPROViSeD — Integrated Modelling of
Protein-complexes Via Single-shot registration using DREAM{% endblock %} {%
block lead %}Fast. Data-Driven. Scalable.{% endblock %} {% block page_content %}
<link rel="stylesheet" href="{{ url_for('static', filename='home.css') }}" />

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      Hey MMP9, I've heard you're quite the ECM disruptor. What's your mission?
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      You heard right! I'm all about clearing paths by breaking down the
      extracellular matrix. But I can't do it alone. What about you, LCN2?
    </p>
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    <p class="speech left top">
      I'm your partner in crime! I trap iron-loving molecules and help you stay
      active. When we team up, we can break through any barrier. But when we're
      unchecked, we contribute to something serious — cancer spread.
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      Right! That's why our interactions are so important to understand. Knowing
      how we work together can help design inhibitors to stop us from aiding
      metastasis.
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    <p class="speech left top">
      Exactly! With <b>IMPROViSeD</b>, scientists are visualizing our structure
      in detail. They're using real data to model how we connect.
    </p>
    <p class="speech right top">
      So, they're creating a blueprint of our partnership?
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      Yes, and that blueprint could be the key to disrupting our dangerous
      dance. It's like turning our strengths against cancer!
    </p>
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    <p class="speech center top">
      Here's to science — revealing our secrets to save lives!
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  <h1>Why Do Protein Complexes Matter?</h1>
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      <div class="cardIcon"><img src="https://static.igem.wiki/teams/5346/home/matter1.png" alt="Biological Functions Icon"></div>
      <div class="cardText"><h4>To Understand Biological Functions</h4></div>
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      <div class="cardIcon"><img src="https://static.igem.wiki/teams/5346/home/matter2.png" alt="Disease Mechanisms Icon"></div>
      <div class="cardText"><h4>Disease Mechanisms</h4></div>
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      <div class="cardIcon"><img src="https://static.igem.wiki/teams/5346/home/matter3.png" alt="Drug Design Icon"></div>
      <div class="cardText"><h4>Drug Design and Development</h4></div>
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      <div class="cardIcon"><img src="https://static.igem.wiki/teams/5346/home/matter4.png" alt="Biotechnology Applications Icon"></div>
      <div class="cardText"><h4>Biotechnology Applications</h4></div>
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  <h1>The IMPROViSeD Advantage</h1>
  <p>IMPROViSeD introduces a one-shot registration approach for protein complex modelling that revolutionizes the process by utilizing experimentally-derived geometric restraints. Unlike traditional methods that rely on random sampling and prediction-heavy algorithms, IMPROViSeD uses DREAM (Distance Restraints and Energy Assisted Modelling) to efficiently map out protein substructures with minimal computational overhead.</p>
    <ul>
      <li><b>IMPROViSeD is Fast.</b> No Monte Carlo or Bayesian inference. Skips exhaustive, random sampling of possible configurations.</li>
      <li><b>IMPROViSeD is Data-Driven.</b> Provides a more reliable and accurate model using experimental data.</li>
      <li><b>IMPROViSeD is Scalable.</b> Suitable for modelling large and complex datasets with ease.</li>
      </li>
    </ul>
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  <h1>Tackling Cancer Metastasis</h1>
  <p>One of the most dangerous aspects of cancer is its ability to metastasize—spread from the original tumor to other parts of the body. The LCN2 and MMP9 complex plays a critical role in degrading the extracellular matrix (ECM), a process that provides passage for cancer cells to invade other tissues.
</p><p>
    By modelling the structure of this complex more accurately, IMPROViSeD aims to unlock new insights into how this mechanism works and how it can be disrupted to prevent metastasis. Through cross-linking mass spectrometry (XLMS), our team is actively studying this complex, shedding light on potential therapeutic interventions.</p>
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  <h4 class="center">Whether you're a researcher looking to improve your understanding of protein structures, or you're interested in the therapeutic applications of this research, IMPROViSeD opens new avenues for exploration.</h4>
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