[NTR] Subclasses of tuft cell of nasal cavity epithelium

[Caroline-99]

DRAFT - not finished

Preferred term label
tuft cell of nasal cavity respiratory epithelium

Synonyms (add reference(s), please)
Gɑ-gustducin high respiratory tuft cell - PMID: 38306414 - (narrow) ?
nasal respiratory solitary chemosensory cell - related synonym? PMID: 38306414
tuft-solitary chemosensory cell (related ?) PMID: 38306414
nasal respiratory tuft cell

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

A tuft cell that is part of the nasal cavity respiratory epithelium, uniquely characterized by Gnat3 expression and absence of neurogranin (PMID: 38306414). Acting as a chemosensor, it detects bitter taste ligands and bacterial signals, maintains epithelial-microbial homeostasis, stimulates antimicrobial peptide secretion, and initiates protective responses. It is a major source of IL-25, promoting type 2 immune responses and potentially contributing to chronic rhinosinusitis (PMID: 30379593)."

PMID: 38306414
PMID: 34932383
PMID: 30379593

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
brush cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
nasal cavity respiratory epithelium

---

Preferred term label
tuft cell of olfactory epithelium

Synonyms (add reference(s), please)
TRPM5+ microvillous cell (narrow synonym ?) - PMID: 38306414
tuft-microvillous cell (related/narrow ?) -PMID: 38306414

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)
A tuft cell that is part of the olfactory epithelium, characterized by a globular body. This cell plays a crucial role in allergen recognition and the regulation of olfactory stem cell proliferation through the production of cysteinyl leukotrienes. Unlike other tuft cells, tuft cell of olfactory epithelium has low to absent expression of taste receptors, including the taste-signaling G protein Gα gustducin, and rarely contacts sensory neurons.

(PMID: 38306414)
doi: https://doi.org/10.1101/2022.09.26.509561

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
tuft cell
olfactory epithelial cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
olfactory epithelium

GO -