[NTR] biliary tuft cell

[Caroline-99]

Please check that the term does not already exist by using the ontology search tool OLS:
https://www.ebi.ac.uk/ols4/ontologies/cl

Preferred term label
biliary tuft cell

Synonyms (add reference(s), please)
gallbladder/extrahepatic bile duct tuft cell (PMID: 35245089) -exact synonym

Definition (free text, with reference(s), please. PubMed ID format is PMID:XXXXXX)

A tuft cell that is part of the extrahepatic biliary tree, including the gallbladder and extrahepatic bile ducts. It shares a core genetic program with intestinal tuft cells but has unique tissue-specific genes related to axon guidance, neural development, immune function, and cholesterol metabolism. Unlike its intestinal counterparts, this cell decreases in number postnatally as bile acid production matures, with its abundance negatively regulated by bile acids. Biliary tuft cell functions as a bile acid-sensitive regulator, suppressing inflammation under homeostatic conditions and modulating microbiome-dependent neutrophil infiltration in biliary tissues.

PMID: 35245089
PMID: 37863104

Parent cell type term (check the hierarchy here https://www.ebi.ac.uk/ols4/ontologies/cl)
brush cell

Anatomical structure where the cell type is found (check Uberon for anatomical structures: https://www.ebi.ac.uk/ols4/ontologies/uberon)
A new grouping uberon term is needed for gallbladder and extrahepatic bile duct - extrahepatic biliary tree

Your ORCID

Additional notes or concerns

capable of some negative regulation of inflammatory response