placement of fertilization phenotypes under cell nucleus phenotype

[anna-anagnostop]

Terms including:

decreased qualitatively fertilization
delayed fertilization
increased fertilization
increased occurrence of fertilization

If you look under 'deceased qualitatively fertilization' you find the MP term 'impaired fertilization' and most of the descendants of this term (e.g. impaired acrosome reaction, impaired sperm penetration of zona pellucida) have nothing to do with a cell nucleus phenotype.

[matentzn]

@anna-anagnostop Can you provide a little more detail; I don't understand this ticket. Remember I have zero idea about the biology here, so I need a very clear breakdown what you see, and what you don't want to see or what you are missing, in clear sentences.

[anna-anagnostop]

So, @sbello and I think that fertilization-related terms, such as 'decreased qualitatively fertilization', 'delayed fertilization', 'increased fertilization' and 'increased occurrence of fertilization' (plus all child terms thereof) do not belong under 'cell nucleus phenotype' UPHENO:0082548.

For example, looking under 'decreased qualitatively fertilization' UPHENO:0082001, we do find MP terms like 'impaired fertilization' and its descendants (e.g. decreased fertilization frequency, impaired acrosome reaction, impaired sperm penetration of zona pellucida) under 'reproductive system physiology phenotype' UPHENO:0002378, as expected.

However, the placement of terms like 'impaired acrosome reaction' or 'impaired sperm penetration of zona pellucida' under cell nucleus phenotype' UPHENO:0082548 is INCORRECT as these processes do not involve the (sperm) nucleus and are not relevant to cell nucleus phenotypes.

I suspect this is likely because the GO term for 'fertilization' GO:0009566 includes 'germ cell nucleus' in its logical definition:

GO also has 'pronuclear fusion' GO:0007344 (defined as The merging of two pronuclei in a fertilized egg to fuse and produce a single zygotic genome) as part of some single fertilization GO:0007338.