diff --git a/tests/integration/test_glibcxx_3_4_25/setup.py b/tests/integration/test_glibcxx_3_4_25/setup.py
new file mode 100644
index 00000000..ae6d279b
--- /dev/null
+++ b/tests/integration/test_glibcxx_3_4_25/setup.py
@@ -0,0 +1,14 @@
+from setuptools import Extension, setup
+
+setup(
+    name="testentropy",
+    version="0.0.1",
+    ext_modules=[
+        Extension(
+            "testentropy",
+            language="c++",
+            sources=["testentropy.cpp"],
+            extra_compile_args=["-std=c++11"],
+        ),
+    ],
+)
diff --git a/tests/integration/test_glibcxx_3_4_25/testentropy.cpp b/tests/integration/test_glibcxx_3_4_25/testentropy.cpp
new file mode 100644
index 00000000..0799f439
--- /dev/null
+++ b/tests/integration/test_glibcxx_3_4_25/testentropy.cpp
@@ -0,0 +1,28 @@
+#include <Python.h>
+#include <random>
+
+static PyObject *
+run(PyObject *self, PyObject *args)
+{
+    (void)self;
+    (void)args;
+    std::random_device rd;
+    return PyLong_FromLong(rd.entropy() >= 0.0 ? 0 : -1);
+}
+
+/* Module initialization */
+PyMODINIT_FUNC PyInit_testentropy(void)
+{
+    static PyMethodDef module_methods[] = {
+        {"run", (PyCFunction)run, METH_NOARGS, "run."},
+        {NULL}  /* Sentinel */
+    };
+    static struct PyModuleDef moduledef = {
+        PyModuleDef_HEAD_INIT,
+        "testentropy",
+        "testentropy module",
+        -1,
+        module_methods,
+    };
+    return PyModule_Create(&moduledef);
+}
diff --git a/tests/integration/test_manylinux.py b/tests/integration/test_manylinux.py
index c2d11232..2eb372d6 100644
--- a/tests/integration/test_manylinux.py
+++ b/tests/integration/test_manylinux.py
@@ -25,12 +25,14 @@
 MANYLINUX2010_IMAGE_ID = f"quay.io/pypa/manylinux2010_{PLATFORM}:latest"
 MANYLINUX2014_IMAGE_ID = f"quay.io/pypa/manylinux2014_{PLATFORM}:latest"
 MANYLINUX_2_24_IMAGE_ID = f"quay.io/pypa/manylinux_2_24_{PLATFORM}:latest"
+MANYLINUX_2_28_IMAGE_ID = f"quay.io/pypa/manylinux_2_28_{PLATFORM}:latest"
 if PLATFORM in {"i686", "x86_64"}:
     MANYLINUX_IMAGES = {
         "manylinux_2_5": MANYLINUX1_IMAGE_ID,
         "manylinux_2_12": MANYLINUX2010_IMAGE_ID,
         "manylinux_2_17": MANYLINUX2014_IMAGE_ID,
         "manylinux_2_24": MANYLINUX_2_24_IMAGE_ID,
+        "manylinux_2_28": MANYLINUX_2_28_IMAGE_ID,
     }
     POLICY_ALIASES = {
         "manylinux_2_5": ["manylinux1"],
@@ -42,6 +44,8 @@
         "manylinux_2_17": MANYLINUX2014_IMAGE_ID,
         "manylinux_2_24": MANYLINUX_2_24_IMAGE_ID,
     }
+    if PLATFORM in {"aarch64", "ppc64le"}:
+        MANYLINUX_IMAGES["manylinux_2_28"] = MANYLINUX_2_28_IMAGE_ID
     POLICY_ALIASES = {
         "manylinux_2_17": ["manylinux2014"],
     }
@@ -60,6 +64,7 @@
     "manylinux_2_12": "devtoolset-8",
     "manylinux_2_17": "devtoolset-10",
     "manylinux_2_24": "devtoolset-not-present",
+    "manylinux_2_28": "gcc-toolset-11",
     "musllinux_1_1": "devtoolset-not-present",
 }
 PATH_DIRS = [
@@ -688,6 +693,46 @@ def test_nonpy_rpath(self, any_manylinux_container, docker_python, io_folder):
             ],
         )
 
+    def test_glibcxx_3_4_25(self, any_manylinux_container, docker_python, io_folder):
+        policy, tag, manylinux_ctr = any_manylinux_container
+        docker_exec(
+            manylinux_ctr,
+            [
+                "bash",
+                "-c",
+                "cd /auditwheel_src/tests/integration/test_glibcxx_3_4_25 && "
+                "if [ -d ./build ]; then rm -rf ./build ./*.egg-info; fi && "
+                "python -m pip wheel --no-deps -w /io .",
+            ],
+        )
+
+        orig_wheel, *_ = os.listdir(io_folder)
+        assert orig_wheel.startswith("testentropy-0.0.1")
+
+        # Repair the wheel using the appropriate manylinux container
+        repair_command = f"auditwheel repair --plat {policy} -w /io /io/{orig_wheel}"
+        if policy.startswith("manylinux_2_28_"):
+            with pytest.raises(CalledProcessError):
+                docker_exec(manylinux_ctr, repair_command)
+            # TODO if a "permissive" mode is implemented, add the relevant flag to the
+            # repair_command here and drop the return statement below
+            return
+
+        docker_exec(manylinux_ctr, repair_command)
+
+        repaired_wheel, *_ = glob.glob(f"{io_folder}/*{policy}*.whl")
+        repaired_wheel = os.path.basename(repaired_wheel)
+
+        docker_exec(docker_python, "pip install /io/" + repaired_wheel)
+        docker_exec(
+            docker_python,
+            [
+                "python",
+                "-c",
+                "from testentropy import run; exit(run())",
+            ],
+        )
+
 
 class TestManylinux(Anylinux):
     @pytest.fixture(scope="session")
diff --git a/tests/integration/testdependencies/dependency.c b/tests/integration/testdependencies/dependency.c
index 30cbb89f..19695ba0 100644
--- a/tests/integration/testdependencies/dependency.c
+++ b/tests/integration/testdependencies/dependency.c
@@ -3,10 +3,15 @@
 #include <stdlib.h>
 #include <stdint.h>
 #include <math.h>
+#if defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 28)
+#include <threads.h>
+#endif
 
 int dep_run()
 {
-#if defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 24)
+#if defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 28)
+    return thrd_equal(thrd_current(), thrd_current()) ? 0 : 1;
+#elif defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 24)
     return (int)nextupf(0.0F);
 #elif defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 17)
     return (int)(intptr_t)secure_getenv("NON_EXISTING_ENV_VARIABLE");
diff --git a/tests/integration/testdependencies/testdependencies.c b/tests/integration/testdependencies/testdependencies.c
index 9379ec6e..10045b0f 100644
--- a/tests/integration/testdependencies/testdependencies.c
+++ b/tests/integration/testdependencies/testdependencies.c
@@ -5,6 +5,9 @@
 #include <stdlib.h>
 #include <stdint.h>
 #include <math.h>
+#if defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 28)
+#include <threads.h>
+#endif
 #endif
 #include <Python.h>
 
@@ -20,6 +23,8 @@ run(PyObject *self, PyObject *args)
 
 #ifdef WITH_DEPENDENCY
     res = dep_run();
+#elif defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 28)
+    res = thrd_equal(thrd_current(), thrd_current()) ? 0 : 1;
 #elif defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 24)
     res = (int)nextupf(0.0F);
 #elif defined(__GLIBC_PREREQ) && __GLIBC_PREREQ(2, 17)