Voltage clamp notebooks

Intro

Recently as 92 not uncommon for patch clampers to build own amplifiers (SAKAKIBARA) and perform detailed modelling (OTHER REF) Commercialisation and specialisation: Experimenter, Hardware expert, Modeller seperate people This paper and notebooks explain patch clamp to modellers Code and equations provided for target audience modellers who analyse voltage clamp data, but hope figures and text also useful for experimenters

Paper contents

1. [notebooks](How it works)
2. [experiments](How to calibrate it / examples of quality of fit)
   • I suspect that everyone can get slightly better results by refitting to their amp
   • Maaaaay redo Chon's experiments with the model cell for this (and redo mine with his cell)
3. Implications for fitting

Journal

• eLife (living article: runnable stuff)
• https://www.sciencedirect.com/journal/the-journal-of-precision-medicine-health-and-disease

Why another one

• Chon's first papers use it, Roman's paper uses it, ex293 paper uses it.
• Lei, Clark & all show its application to INa
• Lei simulator paper will be (should be!) aimed at massive market of non-programming experiments
• Some paper can still introduce or use the current clamp model
• INa artefact paper will use it behind the scenes
• This paper specifically for people who analyse voltage clamp data with models, and who want to understand amplifier by modeling it.