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Fixes #2909 NTR- tuft cell of thymus #2912

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merged 4 commits into from
Jan 17, 2025
Merged

Fixes #2909 NTR- tuft cell of thymus #2912

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8c87fd5
Fixes #2909 NTR- tuft cell of thymus
Caroline-99 Jan 16, 2025
af1d7b4
Update cl-edit.owl
Caroline-99 Jan 16, 2025
a12af28
Updated definition and added a link to GO
Caroline-99 Jan 17, 2025
5b2556a
Merge branch 'master' into 2909-ntr-tuft-cell-of-thymus
Caroline-99 Jan 17, 2025
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13 changes: 13 additions & 0 deletions src/ontology/cl-edit.owl
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Original file line number Diff line number Diff line change
Expand Up @@ -3146,6 +3146,7 @@ Declaration(Class(obo:CL_4052029))
Declaration(Class(obo:CL_4052030))
Declaration(Class(obo:CL_4052031))
Declaration(Class(obo:CL_4052032))
Declaration(Class(obo:CL_4052034))
Declaration(Class(obo:CL_4052048))
Declaration(Class(obo:CL_4052049))
Declaration(Class(obo:CP_0000000))
Expand Down Expand Up @@ -33504,6 +33505,18 @@ AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:35389781") rdfs:comment
AnnotationAssertion(rdfs:label obo:CL_4052032 "granzyme H-associated CD8 T cell")
EquivalentClasses(obo:CL_4052032 ObjectIntersectionOf(obo:CL_0000909 ObjectSomeValuesFrom(obo:RO_0002292 obo:PR_000003490)))

# Class: obo:CL_4052034 (tuft cell of thymus)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30904566") Annotation(oboInOwl:hasDbXref "PMID:36961668") obo:IAO_0000115 obo:CL_4052034 "A tuft cell that is part of the medullary epithelium of the thymus, characterized by lateral microvilli and specific markers such as L1CAM and MHC II. This cell is pivotal in immune functions such as antigen presentation, central tolerance, and type 2 immunity. It exhibits characteristics of both medullary thymic epithelial cells (mTECs) and peripheral tuft cells, with its development governed by transcription factors like POU2F3.")
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AnnotationAssertion(terms:contributor obo:CL_4052034 <https://orcid.org/0009-0000-8480-9277>)
AnnotationAssertion(terms:date obo:CL_4052034 "2025-01-16T11:29:54Z"^^xsd:dateTime)
AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30904566") oboInOwl:hasExactSynonym obo:CL_4052034 "thymic tuft cell")
AnnotationAssertion(oboInOwl:hasExactSynonym obo:CL_4052034 "tuft cell of thymic epithelium")
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AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30904566") rdfs:comment obo:CL_4052034 "A thymic tuft cell is a subset of terminally differentiated medullary thymic epithelial cell (mTEC) comprising 5-10% of total mTECs. Lineage-tracing studies indicate that this cell arises from mature MHCII⁺⁺ mTECs, with development occurring through both Aire-dependent and Aire-independent pathways. However, its exact origins remain unclear.")
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AnnotationAssertion(rdfs:label obo:CL_4052034 "tuft cell of thymus")
EquivalentClasses(obo:CL_4052034 ObjectIntersectionOf(obo:CL_0002204 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0003846)))
SubClassOf(obo:CL_4052034 ObjectSomeValuesFrom(obo:BFO_0000050 obo:UBERON_0002124))

# Class: obo:CL_4052048 (intercalated cell of salivary gland)

AnnotationAssertion(Annotation(oboInOwl:hasDbXref "PMID:30855909") Annotation(oboInOwl:hasDbXref "PMID:35799078") Annotation(oboInOwl:hasDbXref "PMID:36726292") Annotation(oboInOwl:hasDbXref "PMID:37724716") obo:IAO_0000115 obo:CL_4052048 "A cuboidal epithelial cell that is part of the intercalated duct of salivary gland. This cell expresses proteins commonly associated with acinar cells and displays calcium signaling characteristics similar to secretory cells, indicating an active role in the secretory process rather than ion reabsorption.")
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