super fast, super good
- Use seeded abPOA mode (in smoothxg). This requires much less memory than the unseeded mode, and allows us to explore much larger POA target lengths (
-G
). - Set a lower POA overlap by default (
-O 0.001
) - Automatically compute
smoothxg -w
as-G * -n
. A specific number of haplotypes can be given via-H
, should this differ from-n
, in which case the window size is set as-G * -H
.
Suggested use: set pggb -k
larger than SINE elements or other short repeats in the genome. For human, we use -k 311
. A long segment length for mapping is also recommended (in human we use -s 100000
). These aren't in the defaults yet, but subsequent releases will have preset settings for different genome lengths and divergences.